articleNucleic Acids ResearchOct 25, 2020GOLD OA

GENCODE 2021

AFAdam FrankishMDMark DiekhansIJIrwin JungreisJLJulien LagardeJLJane Loveland

European Bioinformatics Institute · University of California, Santa Cruz · +18 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

The GENCODE project annotates human and mouse genes and transcripts supported by experimental data with high accuracy, providing a foundational resource that supports genome biology and clinical genomics. GENCODE annotation processes make use of primary data and bioinformatic tools and analysis generated both within the consortium and externally to support the creation of transcript structures and the determination of their function. Here, we present improvements to our annotation infrastructure, bioinformatics tools, and analysis, and the advances they support in the annotation of the human and mouse genomes including: the completion of first pass manual annotation for the mouse reference genome; targeted…

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Authors

56

Topics & keywords

Topics
Keywords
  • Ensembl
  • Annotation
  • Biology
  • Genome project
  • Genome
  • Genome browser
  • Gene Annotation
  • Computational biology
UN Sustainable Development Goals
  • Industry, innovation and infrastructure
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