Heavy-Atom-Free Photosensitizers: From Molecular Design to Applications in the Photodynamic Therapy of Cancer
Ewha Womans University · Duy Tan University · +2 more institutions
Abstract
ConspectusPhotodynamic therapy (PDT) is a clinically approved therapeutic modality that has shown great potential for the treatment of cancers owing to its excellent spatiotemporal selectivity and inherently noninvasive nature. However, PDT has not reached its full potential, partly due to the lack of ideal photosensitizers. A common molecular design strategy for effective photosensitizers is to incorporate heavy atoms into photosensitizer structures, causing concerns about elevated dark toxicity, short triplet-state lifetimes, poor photostability, and the potentially high cost of heavy metals. To address these drawbacks, a significant advance has been devoted to developing advanced smart photosensitizers…
Citation impact
- FWCI
- 25.52
- Percentile
- 100%
- References
- 72
Authors
4Topics & keywords
- Photodynamic therapy
- Photosensitizer
- Chemistry
- Nanotechnology
- Atom (system on chip)
- Design elements and principles
- Combinatorial chemistry
- Photochemistry