articleVirus EvolutionApr 12, 2020GOLD OA

RDP5: a computer program for analyzing recombination in, and removing signals of recombination from, nucleotide sequence datasets

University of Cape Town · Arizona State University · +10 more institutions

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Abstract

For the past 20 years, the recombination detection program (RDP) project has focused on the development of a fast, flexible, and easy to use Windows-based recombination analysis tool. Whereas previous versions of this tool have relied on considerable user-mediated verification of detected recombination events, the latest iteration, RDP5, is automated enough that it can be integrated within analysis pipelines and run without any user input. The main innovation enabling this degree of automation is the implementation of statistical tests to identify recombination signals that could be attributable to evolutionary processes other than recombination. The additional analysis time required for these tests has been…

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