Enhanced SARS-CoV-2 neutralization by dimeric IgA

Wang, Zijun; Lorenzi, Julio C. C.; Muecksch, Frauke; Finkin, Shlomo; Viant, Charlotte; Gaebler, Christian; Cipolla, Melissa; Hoffmann, Hans-Heinrich; Oliveira, Thiago Y.; Oren, Deena A.; Ramos, Víctor; Nogueira, Lilian; Michailidis, Eleftherios; Robbiani, Davide F.; Gazumyan, Anna; Rice, Charles M.; Hatziioannou, Théodora; Bieniasz, Paul D.; Caskey, Marina; Nussenzweig, Michel C.

doi:10.1126/scitranslmed.abf1555

articleScience Translational MedicineDec 8, 2020HYBRID OA

Enhanced SARS-CoV-2 neutralization by dimeric IgA

ZWZijun Wang JCJulio C. C. Lorenzi FMFrauke Muecksch SFShlomo Finkin CVCharlotte Viant

Rockefeller University · Università della Svizzera italiana · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), primarily infects cells at mucosal surfaces. Serum neutralizing antibody responses are variable and generally low in individuals that suffer mild forms of COVID-19. Although potent immunoglobulin G (IgG) antibodies can neutralize the virus, less is known about secretory antibodies such as IgA that might affect the initial viral spread and transmissibility from the mucosa. Here, we characterize the IgA response to SARS-CoV-2 in a cohort of 149 convalescent individuals after diagnosis with COVID-19. IgA responses in plasma generally correlated with IgG responses. Furthermore, clones of IgM-,…

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Topics & keywords

Topics

Keywords

Neutralization
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Antibody
Coronavirus disease 2019 (COVID-19)
Chemistry
Virology
2019-20 coronavirus outbreak
Sars virus

UN Sustainable Development Goals

Zero hunger

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