articleNatureDec 11, 2020HYBRID OA

Genetic mechanisms of critical illness in COVID-19

TGThe GenOMICC InvestigatorsEPErola Pairo‐CastineiraTIThe ISARIC4C InvestigatorsTCThe COVID-19 Human Genetics Initiative2I23andMe Investigators

Roslin Institute · Centre for Inflammation Research · +45 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Host-mediated lung inflammation is present 1 , and drives mortality 2 , in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development 3 . Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 10 -8 ) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2…

Citation impact

1,491
total citations
FWCI
97.85
Percentile
100%
References
101
Citations per year

Authors

72
  • TG
    The GenOMICC InvestigatorsCorresponding

    Roslin Institute, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh

  • EP
    Erola Pairo‐Castineira

    Roslin Institute, Western General Hospital, Institute of Genetics and Cancer, University of Edinburgh

  • TI
    The ISARIC4C Investigators

    Western General Hospital, Centre for Inflammation Research, Institute of Genetics and Cancer, The Queen's Medical Research Institute, University of Edinburgh

  • TC
    The COVID-19 Human Genetics Initiative

    Western General Hospital, Institute of Genetics and Cancer, University of Edinburgh

  • 2I
    23andMe Investigators

    Roslin Institute, University of Edinburgh

Topics & keywords

Topics
Keywords
  • Biology
  • Genome-wide association study
  • Genetics
  • Gene
  • Candidate gene
  • Single-nucleotide polymorphism
  • Bioinformatics
  • Genotype
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding