UniProt: the universal protein knowledgebase in 2021

The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly…

• EB
  European Bioinformatics Institute
• EM
  European Molecular Biology Laboratory
• AG
  Australian Government
• BH
  British Heart Foundation

  Award: RG/13/5/30112
• SI
  Swiss Institute of Bioinformatics
• NI
  National Institutes of Health

  Awards: R01GM080646, U41HG002273, U24HG007822, P20GM103446
• DF
  Directorate for Biological Sciences
• BA
  Biotechnology and Biological Sciences Research Council

  Awards: BB/T010541/1, BB/S01781X/1, BB/M011674/1, BB/T010541/1
• SF
  Staatssekretariat für Bildung, Forschung und Innovation
• NH
  National Heart, Lung, and Blood Institute

  Award: U24HG007822
• NI
  National Institute of Mental Health

  Award: U24HG007822
• NH
  National Human Genome Research Institute

  Award: U41HG002273
• NE
  National Eye Institute
• NC
  National Cancer Institute

  Award: U24HG007822
• NI
  National Institute of General Medical Sciences

  Awards: U24HG007822, R01GM080646, P20GM103446
• NI
  National Institute of Allergy and Infectious Diseases

  Award: U24HG007822
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: U24HG007822