The Gene Ontology resource: enriching a GOld mine

The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review…

• NS
  National Science Foundation

  Awards: IOS #1127112, 1565146, P20GM103446, 1458400, 1340112
• WT
  Wellcome Trust

  Awards: 108433/Z/15/Z, 212925/Z/18/Z, 104967/Z/14/Z
• EM
  European Molecular Biology Laboratory

  Awards: OTAR02-048, OTAR-044
• AG
  Australian Government
• AR
  Alzheimer’s Research UK

  Award: ARUK-NAS2017A-1
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  Norges Forskningsråd

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• NI
  National Institutes of Health

  Awards: U01GM120953, R01GM080646, HG002659, U41HG002273, HG010859, U41HG007822, GM089636, U24HG007822, P20GM103446, ARUK-NAS2017A-1, U41 HG02273
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  Directorate for Biological Sciences

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  Medical Research Council

  Awards: MR/S000453/1, MR/N030117/1, MR/N030117/1, MR/S000453/1
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  Biotechnology and Biological Sciences Research Council

  Awards: BB/L024136/1, BB/M011674/1, BB/N00521X/1, BB/N019172/1, BB/L024136/1, BB/P024610, BB/N019172/1, BB/P024602, BB/N00521X/1, BB/M011674/1
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  Staatssekretariat für Bildung, Forschung und Innovation
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  National Heart, Lung, and Blood Institute

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  National Institute of Mental Health

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  National Human Genome Research Institute

  Awards: U41HG002273, HG010859, U24-HG002223, HG 002273, HG002659, U41 HG02273, U41 HG001315, HG 000330, U24 HG002223, U41HG007822, U41HG000739, HG 003751
• NE
  National Eye Institute
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  National Institute of General Medical Sciences

  Awards: U41HG007822, 1R24GM137770-01, U24HG007822, U01GM120953, R01GM080646, P20GM103446
• NI
  National Institute of Allergy and Infectious Diseases

  Award: U24HG007822
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: U24HG007822