Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance
Sichuan University · West China Hospital of Sichuan University
Indexed incrossrefdoajpubmed
Abstract
MtROS can promote renal injury by suppressing TFAM-mediated mtDNA maintenance, resulting in decreased mitochondrial energy metabolism and increased cytokine release. TFAM defects may be a promising target for renal repair after IRI-AKI.
Citation impact
775
total citations
- FWCI
- 40.17
- Percentile
- 100%
- References
- 58
Citations per year
Authors
11- MZMeng ZhaoCorresponding
Sichuan University, West China Hospital of Sichuan University
- YWYizhuo Wang
Sichuan University, West China Hospital of Sichuan University
- LLLing Li
Sichuan University, West China Hospital of Sichuan University
- SLShuyun Liu
Sichuan University, West China Hospital of Sichuan University
- CWChengshi Wang
Sichuan University, West China Hospital of Sichuan University
Topics & keywords
Topics
Keywords
- TFAM
- Mitochondrial DNA
- Inflammation
- Mitochondrion
- Acute kidney injury
- Medicine
- Biology
- Cell biology
No related works found for this paper.