Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms
Chinese Academy of Sciences · Shenzhen Institutes of Advanced Technology · +1 more institution
Abstract
The blood-brain barrier (BBB) is an important physiological barrier that separates the central nervous system (CNS) from the peripheral circulation, which contains inflammatory mediators and immune cells. The BBB regulates cellular and molecular exchange between the blood vessels and brain parenchyma. Normal functioning of the BBB is crucial for the homeostasis and proper function of the brain. It has been demonstrated that peripheral inflammation can disrupt the BBB by various pathways, resulting in different CNS diseases. Recently, clinical research also showed CNS complications following SARS-CoV-2 infection and chimeric antigen receptor (CAR)-T cell therapy, which both lead to a cytokine storm in the…
Citation impact
- FWCI
- 20.57
- Percentile
- 100%
- References
- 168
Authors
3- XHXiaowen Huang
Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, University of Chinese Academy of Sciences
- BHBasharat Hussain
Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology, University of Chinese Academy of Sciences
- JCJunlei ChangCorresponding
Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology
Topics & keywords
- Inflammation
- Blood–brain barrier
- Immune system
- Central nervous system
- Context (archaeology)
- Neuroscience
- Medicine
- Microglia
- Good health and well-being