The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment
Shanghai Ninth People's Hospital
Indexed incrossrefdoajpubmed
Abstract
The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment (TME). Recently, TME modulation strategies have attracted much attention in cancer immunotherapy. Despite the preliminary success of immunotherapeutic agents, their therapeutic effects have been restricted by the limited retention time of drugs in TME. Compared with traditional delivery systems, nanoparticles with unique physical properties and elaborate design can efficiently penetrate TME and specifically deliver to the major components in TME. In this review, we briefly introduce the substitutes of TME including dendritic cells, macrophages, fibroblasts, tumor vasculature, tumor-draining…
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672
total citations
- FWCI
- 29.56
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- 100%
- References
- 162
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Authors
4Topics & keywords
Topics
Keywords
- Tumor microenvironment
- Immunotherapy
- Radiation therapy
- Cancer research
- Cancer immunotherapy
- Metastasis
- Cancer therapy
- Cancer
UN Sustainable Development Goals
- Good health and well-being
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