reviewAgeing Research ReviewsDec 28, 2020HYBRID OA

The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis

LZLinli ZhengZZZiji ZhangPSPuyi ShengAMAli Mobasheri

Sun Yat-sen University · The First Affiliated Hospital, Sun Yat-sen University · +4 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to changes in the inflammatory microenvironment and may play a key role in cartilage degeneration and OA progression. Under conditions of environmental stress, chondrocytes tend to adapt their metabolism to microenvironmental changes by shifting from one metabolic pathway to another, for example from oxidative phosphorylation to glycolysis. Similar changes occur in other joint cells, including synoviocytes. Switching between these pathways is implicated in metabolic alterations that involve mitochondrial dysfunction, enhanced…

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Authors

4

Topics & keywords

Topics
Keywords
  • AMPK
  • Glycolysis
  • Chondrocyte
  • Metabolic pathway
  • Oxidative phosphorylation
  • Biology
  • Mechanistic target of rapamycin
  • PI3K/AKT/mTOR pathway
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