The emerging role of Nrf2 in mitochondrial function
Johns Hopkins University · University of Dundee · +2 more institutions
Abstract
The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti-inflammatory, and detoxification enzymes as well as proteins that assist in the repair or removal of damaged macromolecules. Nrf2 has a crucial role in the maintenance of cellular redox homeostasis by regulating the biosynthesis, utilization, and regeneration of glutathione, thioredoxin, and NADPH and by controlling the production of reactive oxygen species by mitochondria and NADPH oxidase. Under homeostatic conditions, Nrf2 affects the mitochondrial membrane…
Citation impact
- FWCI
- 27.40
- Percentile
- 100%
- References
- 114
Authors
2Topics & keywords
- Mitochondrion
- Cell biology
- Transcription factor
- Mitochondrial biogenesis
- Biology
- Mitophagy
- Biochemistry
- Reactive oxygen species