articleCell Death and DiseaseJan 13, 2022GOLD OA

Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts

CZChong ZhangXWXiang-Yu WangPZPeng ZhangTHTao-Chen HeJHJia-Hao Han

Fudan University · Huashan Hospital · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Tumor metastasis is a hallmark of cancer. The communication between cancer-derived exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche formation and cancer metastasis. However, the mechanisms underlying exosome-mediated pre-metastatic niche formation during colorectal cancer (CRC) liver metastasis remain incompletely understood. Here we identified HSPC111 was the leading upregulated gene in hepatic stellate cells (HSCs) incubated with CRC cell-derived exosomes. In xenograft mouse model, CRC cell-derived exosomal HSPC111 facilitated pre-metastatic niche formation and CRC liver metastases (CRLM). Consistently, CRC patients with liver metastasis had higher level of HSPC111 in…

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257
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100%
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Authors

13
  • CZ
    Chong ZhangCorresponding

    Fudan University, Huashan Hospital

  • XW
    Xiang-Yu Wang

    Fudan University, Huashan Hospital

  • PZ
    Peng Zhang

    Fudan University, Huashan Hospital

  • TH
    Tao-Chen He

    Fudan University, Huashan Hospital

  • JH
    Jia-Hao Han

    Fudan University, Huashan Hospital

Topics & keywords

Topics
Keywords
  • Metastasis
  • Microvesicles
  • Lipid metabolism
  • Downregulation and upregulation
  • Colorectal cancer
  • microRNA
  • Reprogramming
  • Hepatic stellate cell
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