Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring

FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples. These correlations motivated the development and on-body validation of an aptamer-FET array–based smartwatch equipped with a custom, multichannel, self-referencing, and autonomous source measurement unit enabling seamless, real-time cortisol sweat sensing.

• NS
  National Science Foundation

  Awards: 1636136, CAREER, 1847729
• PR
  Pharmaceutical Research and Manufacturers of America Foundation
• IH
  Intermountain Healthcare
• HM
  Henry M. Jackson Foundation
• NI
  National Institute of General Medical Sciences

  Award: GM138843
• DO
  Division of Civil, Mechanical and Manufacturing Innovation

  Awards: 1636136, CAREER, CMMI-1636136
• CN
  California NanoSystems Institute