reviewFrontiers in GeneticsJan 10, 2022GOLD OA

Bacterial Response to Oxidative Stress and RNA Oxidation

AFAndré F. SeixasAPAna Patrícia QuenderaJPJoão Pedro Abreu SousaAFAlda Filipa Queirós SilvaCMCecília M. Arraiano

Universidade Nova de Lisboa

PubMed
Indexed incrossrefdoajpubmed

Abstract

Bacteria have to cope with oxidative stress caused by distinct Reactive Oxygen Species (ROS), derived not only from normal aerobic metabolism but also from oxidants present in their environments. The major ROS include superoxide O 2 − , hydrogen peroxide H 2 O 2 and radical hydroxide HO • . To protect cells under oxidative stress, bacteria induce the expression of several genes, namely the SoxRS, OxyR and PerR regulons. Cells are able to tolerate a certain number of free radicals, but high levels of ROS result in the oxidation of several biomolecules. Strikingly, RNA is particularly susceptible to this common chemical damage. Oxidation of RNA causes the formation of strand breaks, elimination of bases or…

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235
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Authors

6

Topics & keywords

Topics
Keywords
  • RNA
  • Reactive oxygen species
  • Oxidative stress
  • Transfer RNA
  • Regulon
  • Biochemistry
  • Bacteria
  • Cell biology
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