Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles
University Health Network · Toronto General Hospital · +8 more institutions
Abstract
Macrophages were the most transcriptionally conserved subset across mouse tissues and between mice and humans, despite organ- and species-specific transcriptional differences. Here, we define the existence of three murine macrophage subpopulations based on common life cycle properties and core gene signatures and provide a common starting point to understand tissue macrophage heterogeneity.
Citation impact
- FWCI
- 37.99
- Percentile
- 100%
- References
- 71
Authors
23- SASarah A. DickCorresponding
University Health Network, Toronto General Hospital, Ted Rogers Centre for Heart Research
- AWAnthony WongCorresponding
University Health Network, University of Toronto, Toronto General Hospital, Ted Rogers Centre for Heart Research
- HHHomaira HamidzadaCorresponding
University Health Network, University of Toronto, Toronto General Hospital, Ted Rogers Centre for Heart Research
- SNSara NejatCorresponding
University Health Network, Toronto General Hospital, Ted Rogers Centre for Heart Research
- RNRobert NechanitzkyCorresponding
University Health Network, Princess Margaret Cancer Centre
Topics & keywords
- Biology
- Macrophage
- Yolk sac
- Monocyte
- CCR2
- Population
- Fate mapping
- Compartment (ship)
- Responsible consumption and production