Colorectal Cancer‐Derived Small Extracellular Vesicles Promote Tumor Immune Evasion by Upregulating PD‐L1 Expression in Tumor‐Associated Macrophages
Jiangnan University · Wuxi Fourth People's Hospital · +1 more institution
Abstract
Abstract Tumor‐associated macrophages (TAMs) are one of the most abundant cell types in colorectal cancer (CRC) tumor microenvironment (TME). Recent studies observed complicated “cross‐talks” between cancer cells and macrophages in TME. However, the underlying mechanisms are still poorly elucidated. Here, PD‐L1 levels are very low in CRC cells but highly abundant in TAMs, and a specific PD‐L1 + CD206 + macrophage subpopulation are identified, which is induced by tumor cells and associated with a poor prognosis. Mechanistic investigations reveal that CRC cells can secrete small extracellular vesicles (sEVs) taken up by macrophages that induce M2 like polarization and PD‐L1 expression, resulting in increased…
Citation impact
- FWCI
- 20.36
- Percentile
- 100%
- References
- 40
Authors
14- YYYuan Yin
Jiangnan University, Wuxi Fourth People's Hospital
- BLBingxin Liu
Jiangnan University, Wuxi Fourth People's Hospital
- YCYulin Cao
Jiangnan University, Wuxi Fourth People's Hospital
- SYSurui Yao
Jiangnan University, Wuxi Fourth People's Hospital
- YLYuhang Liu
Jiangnan University, Wuxi Fourth People's Hospital
Topics & keywords
- Tumor microenvironment
- Macrophage polarization
- Cancer research
- M2 Macrophage
- Immune system
- Tumor-associated macrophage
- Microvesicles
- PTEN