reviewCancer CommunicationsJan 12, 2022GOLD OA

New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

Jinan University · First Affiliated Hospital of Zhengzhou University · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

With the development of proteomics and epigenetics, a large number of RNA-binding proteins (RBPs) have been discovered in recent years, and the interaction between long non-coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in-depth research on the lncRNA-RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA-RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization,…

Citation impact

289
total citations
FWCI
26.48
Percentile
100%
References
166
Citations per year

Authors

7

Topics & keywords

Keywords
  • RNA-binding protein
  • Biology
  • Computational biology
  • Epigenetics
  • Interaction network
  • Context (archaeology)
  • RNA
  • Protein–protein interaction
UN Sustainable Development Goals
  • Good health and well-being
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