articleNature CommunicationsJan 11, 2022GOLD OA

Gut microbiota promotes cholesterol gallstone formation by modulating bile acid composition and biliary cholesterol secretion

HHHai HuWSWentao ShaoQLQian LiuNLNing LiuQWQihan Wang

Shanghai East Hospital · Southeast University · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Abstract Cholesterol gallstone disease is a worldwide common disease. Cholesterol supersaturation in gallbladder bile is the prerequisite for its pathogenesis, while the mechanism is not completely understood. In this study, we find enrichment of gut microbiota (especially Desulfovibrionales) in patients with gallstone disease. Fecal transplantation of gut microbiota from gallstone patients to gallstone-resistant strain of mice can induce gallstone formation. Carrying Desulfovibrionales is associated with enhanced cecal secondary bile acids production and increase of bile acid hydrophobicity facilitating intestinal cholesterol absorption. Meanwhile, the metabolic product of Desulfovibrionales , H 2 S increase…

Citation impact

248
total citations
FWCI
21.22
Percentile
100%
References
55
Citations per year

Authors

15
  • HH
    Hai HuCorresponding

    Shanghai East Hospital

  • WS
    Wentao Shao

    Shanghai East Hospital, Southeast University, Nanjing Medical University

  • QL
    Qian Liu

    Soochow University, Nanjing Medical University

  • NL
    Ning Liu

    Shanghai Jiao Tong University

  • QW
    Qihan Wang

    Shanghai East Hospital

Topics & keywords

Topics
Keywords
  • Cholesterol
  • Bile acid
  • Cholesterol 7 alpha-hydroxylase
  • Gut flora
  • Secretion
  • CYP8B1
  • Reverse cholesterol transport
  • Enterohepatic circulation
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