reviewAnnual Review of NeuroscienceJan 5, 2022BRONZE OA

Challenges of Organoid Research

MGMadeline G. AndrewsARArnold R. Kriegstein

University of California, San Francisco · Broad Center

PubMed
Indexed incrossrefpubmed

Abstract

Organoids are 3D cell culture systems derived from human pluripotent stem cells that contain tissue resident cell types and reflect features of early tissue organization. Neural organoids are a particularly innovative scientific advance given the lack of accessibility of developing human brain tissue and intractability of neurological diseases. Neural organoids have become an invaluable approach to model features of human brain development that are not well reflected in animal models. Organoids also hold promise for the study of atypical cellular, molecular, and genetic features that underscore neurological diseases. Additionally, organoids may provide a platform for testing therapeutics in human cells and are…

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240
total citations
FWCI
19.75
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100%
References
90
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Organoid
  • Induced pluripotent stem cell
  • Neuroscience
  • Cell type
  • Human brain
  • Biology
  • Human Induced Pluripotent Stem Cells
  • Stem cell
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