Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells
The Catholic University of Korea Seoul St. Mary's Hospital · Catholic University of Korea · +1 more institution
Abstract
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies that cause RA have been achieved, despite the fact that much remains to be elucidated. This review provides an updated pathogenesis of RA which will unveil novel therapeutic targets.
Citation impact
- FWCI
- 79.11
- Percentile
- 100%
- References
- 136
Authors
3- SJSun‐Hee Jang
The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea
- EKEui-Jong Kwon
Ministry of National Defense, The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea
- JLJennifer LeeCorresponding
The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea
Topics & keywords
- Rheumatoid arthritis
- Immunology
- Pannus
- Autoantibody
- Pathogenesis
- Chemokine
- Medicine
- Immune system
- Good health and well-being