Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the greatest impact on human health. Of the hallmarks of ageing, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is a cell state of irreversible proliferative arrest driven by different types of stress, including oncogene-induced stress. Many senescent cells (SnCs) develop a senescent-associated secretory phenotype (SASP) comprising pro-inflammatory cytokines, chemokines, proteases, bioactive lipids, inhibitory molecules, extracellular vesicles, metabolites, lipids and other…

• MJ
  Michael J. Fox Foundation for Parkinson's Research

  Award: ASAP‐000592
• GF
  Glenn Foundation for Medical Research
• NI
  National Institute on Aging

  Awards: U19 AG056278, RO1 AG063543, P01 AG043376, P01 AG062413, AG063543‐02S1