Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation
Emory University · Wuhan University · +5 more institutions
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Abstract
Objective
This study is to investigate the role of gut dysbiosis in triggering inflammation in the brain and its contribution to Alzheimer's disease (AD) pathogenesis.
Design
We analysed the gut microbiota composition of 3×Tg mice in an age-dependent manner. We generated germ-free 3×Tg mice and recolonisation of germ-free 3×Tg mice with fecal samples from both patients with AD and age-matched healthy donors.
Citation impact
440
total citations
- FWCI
- 34.74
- Percentile
- 100%
- References
- 78
Citations per year
Authors
10Topics & keywords
Topics
Keywords
- Dysbiosis
- Neuroinflammation
- Gut flora
- Microbiome
- Gut–brain axis
- Inflammation
- Immunology
- Biology
UN Sustainable Development Goals
- Good health and well-being
No related works found for this paper.
Funding
- EUEmory UniversityAward: P30 AG066511
- GCGeorgia Clinical and Translational Science AllianceAward: UL1TR002378
- NINational Institutes of HealthAwards: AG065177, UL1TR002378, P30 AG066511, AG066511
- ADAlzheimer's Disease Research Center, Emory UniversityAward: P30 AG066511
- SOSchool of Medicine, Emory UniversityAward: UL1TR002378