Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review
Centro Universitário do Espírito Santo · The University of Texas Health Science Center · +3 more institutions
Abstract
A biomarker describes a measurable indicator of a patient's clinical condition that can be measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis, early disease recognition, risk stratification, appropriate treatment (theranostics), and trial enrichment for patients with sepsis or suspected sepsis. In this narrative review, we aim to answer the question, "Do biomarkers in patients with sepsis or septic shock predict mortality, multiple organ dysfunction syndrome (MODS), or organ dysfunction?" We also discuss the role of pro- and anti-inflammatory biomarkers and biomarkers associated with intestinal permeability, endothelial injury, organ dysfunction, blood-brain barrier (BBB)…
Citation impact
- FWCI
- 64.57
- Percentile
- 100%
- References
- 107
Authors
4- TBTatiana BarichelloCorresponding
Centro Universitário do Espírito Santo, The University of Texas Health Science Center, Universidade do Extremo Sul Catarinense
- JSJaqueline S. Generoso
Centro Universitário do Espírito Santo
- MSMervyn Singer
Bury College, University College London
- FDFelipe Dal‐Pizzol
Centro Universitário do Espírito Santo
Topics & keywords
- Sepsis
- Medicine
- Organ dysfunction
- Biomarker
- Systemic inflammatory response syndrome
- Septic shock
- Multiple organ dysfunction syndrome
- Intensive care medicine
- Good health and well-being