Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy

Tumor-derived exosome can suppress dendritic cells (DCs) and T cells functions. Excessive secretion of exosomal programmed death-ligand 1 (PD-L1) results in therapeutic resistance to PD-1/PD-L1 immunotherapy and clinical failure. Restored T cells by antiexosomal PD-L1 tactic can intensify ferroptosis of tumor cells and vice versa. Diminishing exosomal suppression and establishing a nexus of antiexosomal PD-L1 and ferroptosis may rescue the discouraging antitumor immunity. Here, we engineered phototheranostic metal-phenolic networks (PFG MPNs) by an assembly of semiconductor polymers encapsulating ferroptosis inducer (Fe3+) and exosome inhibitor (GW4869). The PFG MPNs elicited superior near-infrared II…

• NN
  National Natural Science Foundation of China

  Awards: 32171318, 32101069
• SA
  Science and Technology Development Fund

  Awards: 0103/2021/A, 0113/2019/A2, 0109/2018/A3, 0011/2019/AKP
• UD
  Universidade de Macau

  Award: SRG2018-00130-FHS
• ST
  Science, Technology and Innovation Commission of Shenzhen Municipality

  Award: SGDX20201103093600004