Physiology and pathophysiology of human airway mucus
University of North Carolina at Chapel Hill · North Carolina State University · +2 more institutions
Abstract
The mucus clearance system is the dominant mechanical host defense system of the human lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid pumping and cough-dependent mechanisms, and mucus transport rates are heavily dependent on mucus concentration. Importantly, mucus transport rates are accurately predicted by the gel-on-brush model of the mucociliary apparatus from the relative osmotic moduli of the mucus and periciliary-glycocalyceal (PCL-G) layers. The fluid available to hydrate mucus is generated by transepithelial fluid transport. Feedback interactions between mucus concentrations and cilia beating, via purinergic signaling, coordinate Na + absorptive vs Cl −…
Citation impact
- FWCI
- 42.00
- Percentile
- 100%
- References
- 670
Authors
4- DBDavid B. Hill
University of North Carolina at Chapel Hill, North Carolina State University, Lung Institute
- BBBrian Button
University of North Carolina at Chapel Hill, Lung Institute
- MRMichael Rubinstein
University of North Carolina at Chapel Hill, Duke University, Lung Institute
- RCRichard C. BoucherCorresponding
University of North Carolina at Chapel Hill, Lung Institute
Topics & keywords
- Pathophysiology
- Mucus
- Physiology
- Airway
- Respiratory physiology
- Biology
- Medicine
- Respiratory system
- Good health and well-being
Funding
- NSNational Science FoundationAward: EFMA-1830957
- CFCystic Fibrosis FoundationAwards: HILL20Y2-OUT, BOUCHE19R0, BOUCHE19XX0, HILL19G0, BUTTON19G0
- NHNational Heart, Lung, and Blood InstituteAwards: UH3HL123645, R01HL125280, P01HL108808, R01HL136961
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAward: P30DK065988