articleJournal of Chemical Information and ModelingJan 6, 2022GREEN OA

Omicron Variant (B.1.1.529): Infectivity, Vaccine Breakthrough, and Antibody Resistance

JCJiahui ChenRWRui WangNBNancy Benovich GilbyGWGuo‐Wei Wei

Michigan State University

PubMed
Indexed incrossrefpubmed

Abstract

The latest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron (B.1.1.529) has ushered panic responses around the world due to its contagious and vaccine escape mutations. The essential infectivity and antibody resistance of the SARS-CoV-2 variant are determined by its mutations on the spike (S) protein receptor-binding domain (RBD). However, a complete experimental evaluation of Omicron might take weeks or even months. Here, we present a comprehensive quantitative analysis of Omicron's infectivity, vaccine breakthrough, and antibody resistance. An artificial intelligence (AI) model, which has been trained with tens of thousands of experimental data and extensively validated by…

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Authors

4

Topics & keywords

Topics
Keywords
  • Infectivity
  • Monoclonal antibody
  • Antibody
  • Virology
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Spike Protein
  • Virus
  • Coronavirus disease 2019 (COVID-19)
UN Sustainable Development Goals
  • Good health and well-being
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