Review on Strategies and Technologies for Exosome Isolation and Purification
Qilu University of Technology · Shandong Academy of Sciences · +2 more institutions
Abstract
Exosomes, a nano-sized subtype of extracellular vesicles secreted from almost all living cells, are capable of transferring cell-specific constituents of the source cell to the recipient cell. Cumulative evidence has revealed exosomes play an irreplaceable role in prognostic, diagnostic, and even therapeutic aspects. A method that can efficiently provide intact and pure exosomes samples is the first step to both exosome-based liquid biopsies and therapeutics. Unfortunately, common exosomal separation techniques suffer from operation complexity, time consumption, large sample volumes and low purity, posing significant challenges for exosomal downstream analysis. Efficient, simple, and affordable methods to…
Citation impact
- FWCI
- 43.66
- Percentile
- 100%
- References
- 129
Authors
7- JCJiaci Chen
Qilu University of Technology, Shandong Academy of Sciences
- PLPeilong Li
Second Hospital of Shandong University
- TZTaiyi Zhang
Qilu University of Technology, Shandong Academy of Sciences
- ZXZhipeng Xu
University of Bristol
- XHXiaowen HuangCorresponding
Qilu University of Technology, Shandong Academy of Sciences
Topics & keywords
- Microvesicles
- Exosome
- Extracellular vesicles
- Isolation (microbiology)
- Computational biology
- Biogenesis
- Nanotechnology
- Liquid biopsy