Pt Decorated Ti 3 C 2 T x MXene with NIR-II Light Amplified Nanozyme Catalytic Activity for Efficient Phototheranostics

The clinical application of photothermal therapy (PTT) is severely limited by the tissue penetration depth of excitation light, and enzyme therapy is hampered by its low therapeutic efficiency. As a two-dimensional ultrathin nanosheet with high absorbance in the near-infrared-II (NIR-II) region, the titanium carbide (Ti3C2) nanosheet can be used as a substrate to anchor functional components, like nanozymes and nanodrugs. Here, we decorate Pt artificial nanozymes on the Ti3C2 nanosheets to synthesize Ti-based MXene nanocomposites (Ti3C2Tx-Pt-PEG). In the tumor microenvironment, the Pt nanoparticles exhibit peroxidase-like (POD-like) activity, which can in situ catalyze hydrogen peroxide to generate hydroxyl…

• NN
  National Natural Science Foundation of China

  Awards: 51972075, 52002091
• NS
  Natural Science Foundation of Shandong Province

  Award: ZR2020ZD42
• FR
  Fundamental Research Funds for the Central Universities