Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

O’Riordan, Kenneth J.; Collins, Michael; Moloney, Gerard M.; Knox, Emily G.; Aburto, María R.; Fülling, Christine; Morley, Shane J.; Clarke, Gerard; Schellekens, Harriët; Cryan, John F.

doi:10.1016/j.mce.2022.111572

reviewMolecular and Cellular EndocrinologyJan 20, 2022HYBRID OA

Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

KJKenneth J. O’Riordan MCMichael Collins GMGerard M. Moloney EGEmily G. Knox MRMaría R. Aburto

University College Cork · APC Microbiome Institute

PubMed

Indexed incrossrefpubmed

Abstract

The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship between the gut microbiota, the metabolites it produces, and the brain will be critical for the subsequent development of new therapeutic approaches, including the identification of novel psychobiotics. A key focus in this regard have been the short-chain fatty acids (SCFAs) produced by bacterial fermentation of dietary fibre, which include butyrate, acetate, and propionate. Ongoing research is focused on the entry of SCFAs into systemic circulation from the gut lumen, their migration to cerebral circulation and across the blood brain barrier, and their…

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Topics & keywords

Topics

Keywords

Butyrate
Brain function
Propionate
Gut flora
Gut–brain axis
Biology
Blood–brain barrier
Neuroscience

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