Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis
Huazhong University of Science and Technology · Union Hospital · +2 more institutions
Abstract
The refractory diabetic wound has remained a worldwide challenge as one of the major health problems. The impaired angiogenesis phase during diabetic wound healing partly contributes to the pathological process. MicroRNA (miRNA) is an essential regulator of gene expression in crucial biological processes and is a promising nucleic acid drug in therapeutic fields of the diabetic wound. However, miRNA therapies have limitations due to lacking an effective delivery system. In the present study, we found a significant reduction of miR-31-5p expression in the full-thickness wounds of diabetic mice compared to normal mice. Further, miR-31-5p has been proven to promote the proliferation, migration, and angiogenesis…
Citation impact
- FWCI
- 18.36
- Percentile
- 100%
- References
- 96
Authors
13- CYChengqi Yan
Huazhong University of Science and Technology, Union Hospital
- JCJing Chen
Huazhong University of Science and Technology, Union Hospital
- CWCheng Wang
Huazhong University of Science and Technology, Union Hospital
- MYMeng Yuan
Huazhong University of Science and Technology, Union Hospital
- YKYu Kang
Union Hospital, Huazhong University of Science and Technology
Topics & keywords
- Microvesicles
- Angiogenesis
- Wound healing
- microRNA
- Electroporation
- Exosome
- Pharmacology
- Medicine
- Good health and well-being