reviewJournal of Biomedical ScienceJan 4, 2022DIAMOND OA

Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

Institute of Cellular and Organismic Biology, Academia Sinica · Institute of Biomedical Sciences, Academia Sinica · +2 more institutions

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Abstract

The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public health crisis that demands the timely creation of new therapeutics and viral detection. Owing to their high specificity and reliability, monoclonal antibodies (mAbs) have emerged as powerful tools to treat and detect numerous diseases. Hence, many researchers have begun to urgently develop Ab-based kits for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Ab drugs for use as COVID-19 therapeutic agents. The detailed structure of the SARS-CoV-2 spike protein is known, and since this protein is key for viral infection, its receptor-binding domain (RBD) has become a major target for therapeutic Ab…

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