articleDZNE PubFeb 11, 2022GREEN OA

In vivo staging of regional amyloid deposition

MJMichel J. GrotheHBHenryk BarthelJSJorge SepulcreMDMartin DyrbaOSOsama Sabri

Institute for Neurodegenerative Disorders · Athinoula A. Martinos Center for Biomedical Imaging · +2 more institutions

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Abstract

To estimate a regional progression pattern of amyloid deposition from cross-sectional amyloid-sensitive PET data and evaluate its potential for in vivo staging of an individual's amyloid pathology.Multiregional analysis of florbetapir (18F-AV45)-PET data was used to determine individual amyloid distribution profiles in a sample of 667 participants from the Alzheimer's Disease Neuroimaging Initiative cohort, including cognitively normal older individuals (CN) as well as patients with mild cognitive impairment and Alzheimer disease (AD) dementia. The frequency of regional amyloid positivity across CN individuals was used to construct a 4-stage model of progressing amyloid pathology, and individual distribution…

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Topics & keywords

Topics
Keywords
  • In vivo
  • Amyloid (mycology)
  • Pathology
  • Deposition (geology)
  • Amyloid β
  • Medicine
  • Chemistry
  • Neuroscience
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