6PPD-Quinone: Revised Toxicity Assessment and Quantification with a Commercial Standard

Stormwater exposure can cause acute mortality of coho salmon (Oncorhynchus kisutch), and 6PPD-quinone (6PPD-Q) was identified as the primary causal toxicant. Commercial standards of 6PPD-Q recently became available; their analysis highlighted a systematic high bias in prior reporting concerning 6PPD-Q. A 6PPD-Q commercial standard was used to re-confirm toxicity estimates in juvenile coho salmon and develop a liquid chromatography-tandem mass spectrometry analytical method for quantification. Peak area responses of the commercial standard were ∼15 times higher than those of in-house standards, and the updated LC50 value (95 ng/L) was ∼8.3-fold lower than that previously reported. These data support prior…

• UE
  U.S. Environmental Protection Agency

  Award: PC-01J18101
• DO
  Division of Chemical, Bioengineering, Environmental, and Transport Systems

  Award: 1803240