reviewAntibioticsJan 20, 2022GOLD OA

Curcumin: Biological Activities and Modern Pharmaceutical Forms

University of Nis

PubMed
Indexed incrossrefdoajpubmed

Abstract

Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo through various mechanisms of action. Numerous studies have identified and characterised the pharmacokinetic, pharmacodynamic, and clinical properties of curcumin. Curcumin has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, and it is used as a wound-healing agent. However, poor curcumin absorption in the small intestine, fast metabolism, and fast systemic elimination cause poor bioavailability of curcumin in human beings. In order to overcome these problems, a number of curcumin formulations…

Citation impact

317
total citations
FWCI
20.65
Percentile
100%
References
229
Citations per year

Authors

6

Topics & keywords

Keywords
  • Curcumin
  • Bioavailability
  • Chemistry
  • Polyphenol
  • Chromatography
  • Extraction (chemistry)
  • High-performance liquid chromatography
  • Sample preparation
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