Therapeutic Implications of Tumor Microenvironment in Lung Cancer: Focus on Immune Checkpoint Blockade
Ospedale Policlinico San Martino · University of Genoa · +2 more institutions
Abstract
In the last decade, the treatment of non-small cell lung cancer (NSCLC) has been revolutionized by the introduction of immune checkpoint inhibitors (ICI) directed against programmed death protein 1 (PD-1) and its ligand (PD-L1), or cytotoxic T lymphocyte antigen 4 (CTLA-4). In spite of these improvements, some patients do not achieve any benefit from ICI, and inevitably develop resistance to therapy over time. Tumor microenvironment (TME) might influence response to immunotherapy due to its prominent role in the multiple interactions between neoplastic cells and the immune system. Studies investigating lung cancer from the perspective of TME pointed out a complex scenario where tumor angiogenesis, soluble…
Citation impact
- FWCI
- 29.22
- Percentile
- 100%
- References
- 176
Authors
10- CGCarlo Genova
Ospedale Policlinico San Martino, University of Genoa
- CDChiara Dellepiane
Ospedale Policlinico San Martino
- PCPaolo Carrega
University of Messina
- SSSara Sommariva
Superconducting and other Innovative Materials and Devices Institute, Ospedale Policlinico San Martino
- GFGuido Ferlazzo
University of Messina
Topics & keywords
- Tumor microenvironment
- Immunotherapy
- Immune system
- Cancer research
- Immune checkpoint
- Lung cancer
- Cancer immunotherapy
- Cytotoxic T cell
- Good health and well-being