Multiple early factors anticipate post-acute COVID-19 sequelae

Su, Yapeng; Yuan, Dan; Chen, Daniel; Ng, Raymond T.; Wang, Kai; Choi, Jongchan; Li, Sarah; Hong, Sunga; Zhang, Rongyu; Xie, Jingyi; Kornilov, Sergey A.; Scherler, Kelsey; Pavlovitch-Bedzyk, Ana Jimena; Dong, Shen; Lausted, Christopher; Lee, Inyoul; Fallen, Shannon; Dai, Chengzhen L.; Baloni, Priyanka; Smith, Brett; Duvvuri, Venkata R.; Anderson, Kristin G.; Li, Jing; Yang, Fan; Duncombe, Caroline J.; McCulloch, Denise J.; Rostomily, Clifford; Troisch, Pamela; Zhou, Jing; Mackay, Sean; DeGottardi, Quinn; May, Damon; Taniguchi, Ruth; Gittelman, Rachel; Klinger, Mark; Snyder, Thomas M.; Roper, Ryan; Wojciechowska, Gladys; Murray, Kim M.; Edmark, Rick; Evans, Simon; Jones, Lesley; Zhou, Yong; Rowen, Lee; Liu, Rachel; Chour, William; Algren, Heather A.; Berrington, William R.; Wallick, Julie A.; Cochran, Rebecca A.; Micikas, Mary; Wrin, Terri; Petropoulos, Christos J.; Cole, Hunter; Fischer, Trevan; Wei, Wei; Hoon, Dave S.�B.; Price, Nathan D.; Subramanian, Naeha; Hill, Joshua A.; Hadlock, Jennifer; Magis, Andrew T.; Ribas, Antoni; Lanier, Lewis L.; Boyd, Scott D.; Bluestone, Jeffrey A.; Chu, Helen Y.; Hood, Leroy; Gottardo, Raphaël; Greenberg, Philip D.; Davis, Mark M.; Goldman, Jason D.; Heath, James R.

doi:10.1016/j.cell.2022.01.014

articleCellJan 25, 2022HYBRID OA

Multiple early factors anticipate post-acute COVID-19 sequelae

YSYapeng Su DYDan Yuan DCDaniel Chen RTRaymond T. Ng KWKai Wang

Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · Institute for Systems Biology · +18 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

T cells exhibited unique dynamics during recovery from COVID-19. Analysis of symptom-associated immunological signatures revealed coordinated immunity polarization into four endotypes, exhibiting divergent acute severity and PASC. We find that immunological associations between PASC factors diminish over time, leading to distinct convalescent immune states. Detectability of most PASC factors at COVID-19 diagnosis emphasizes the importance of early disease measurements for understanding emergent chronic conditions and suggests PASC treatment strategies.

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1,179

total citations

FWCI: 140.23
Percentile: 100%
References: 87

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73

Topics & keywords

Topics

Keywords

Convalescence
Biology
Coronavirus disease 2019 (COVID-19)
Immune system
Virus
Disease
Immunology
Virology

UN Sustainable Development Goals

Good health and well-being

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