Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron

Cui, Zhen; Liu, Pan; Wang, Nan; Wang, Lei; Fan, Kaiyue; Zhu, Qianhui; Wang, Kang; Chen, Ruihong; Feng, Rui; Jia, Zijing; Yang, Minnan; Xu, Ge; Zhu, Boling; Fu, Wangjun; Chu, Tianming; Feng, Leilei; Wang, Yide; Pei, Xinran; Yang, Peng; Xie, Xiaoliang Sunney; Cao, Lei; Cao, Yunlong; Wang, Xiangxi

doi:10.1016/j.cell.2022.01.019

articleCellJan 25, 2022HYBRID OA

Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron

ZCZhen Cui PLPan Liu NWNan Wang LWLei Wang KFKaiyue Fan

Chinese Academy of Sciences · Institute of Biophysics · +3 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The SARS-CoV-2 Omicron variant with increased fitness is spreading rapidly worldwide. Analysis of cryo-EM structures of the spike (S) from Omicron reveals amino acid substitutions forging interactions that stably maintain an active conformation for receptor recognition. The relatively more compact domain organization confers improved stability and enhances attachment but compromises the efficiency of the viral fusion step. Alterations in local conformation, charge, and hydrophobic microenvironments underpin the modulation of the epitopes such that they are not recognized by most NTD- and RBD-antibodies, facilitating viral immune escape. Structure of the Omicron S bound with human ACE2, together with the…

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Topics & keywords

Topics

Keywords

Biology
Infectivity
Epitope
Immune system
Immune escape
Peptide sequence
Virology
Antibody

UN Sustainable Development Goals

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