Advances in the pathogenesis of psoriasis: from keratinocyte perspective
Tongji University · Shanghai Skin Disease Hospital
Abstract
Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis.
Citation impact
- FWCI
- 44.38
- Percentile
- 100%
- References
- 148
Authors
5- XZXue ZhouCorresponding
Tongji University, Shanghai Skin Disease Hospital
- YCYoudong Chen
Tongji University, Shanghai Skin Disease Hospital
- LCLian Cui
Tongji University, Shanghai Skin Disease Hospital
- YSYuling Shi
Tongji University, Shanghai Skin Disease Hospital
- CGChunyuan Guo
Tongji University, Shanghai Skin Disease Hospital
Topics & keywords
- Psoriasis
- Pathogenesis
- Keratinocyte
- Immunology
- Immune system
- Biology
- Transcription factor
- Disease
- Good health and well-being