Biomimetic Nanoerythrosome‐Coated Aptamer–DNA Tetrahedron/Maytansine Conjugates: pH‐Responsive and Targeted Cytotoxicity for HER2‐Positive Breast Cancer
Sichuan University · State Key Laboratory of Oral Diseases · +1 more institution
Abstract
DNA materials have emerged as potential nanocarriers for targeted cancer therapy to precisely deliver cargos with specific purposes. The short half-life and low bioavailability of DNA materials due to their interception by the reticuloendothelial system and blood clearance further limit their clinical translation. This study employs an HER2-targeted DNA-aptamer-modified DNA tetrahedron (HApt-tFNA) as a drug delivery system, and combines maytansine (DM1) to develop the HApt-DNA tetrahedron/DM1 conjugate (HApt-tFNA@DM1, HTD, HApDC) for targeted therapy of HER2-positive cancer. To optimize the pharmacokinetics and tumor-aggregation of HTD, a biomimetic camouflage is applied to embed HTD. The biomimetic camouflage…
Citation impact
- FWCI
- 23.82
- Percentile
- 100%
- References
- 66
Authors
8- WMWenjuan Ma
Sichuan University, State Key Laboratory of Oral Diseases
- YYYuting Yang
Sichuan University, State Key Laboratory of Oral Diseases
- JZJianwei Zhu
University of Electronic Science and Technology of China
- WJWeiqiang Jia
University of Electronic Science and Technology of China
- TZTao Zhang
Sichuan University, State Key Laboratory of Oral Diseases
Topics & keywords
- Nanocarriers
- Aptamer
- Nanomedicine
- Drug delivery
- Materials science
- Targeted drug delivery
- Nanotechnology
- Liposome
- Good health and well-being