reviewInternational Journal of Molecular SciencesFeb 6, 2022GOLD OA

A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Nanotherapeutics

RNRichard Nii Lante LampteyBCBivek ChaulagainRTRiddhi TrivediAGAvinash GothwalBLBuddhadev Layek

North Dakota State University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Neurodegenerative disorders are primarily characterized by neuron loss. The most common neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there are several medicines currently approved for managing neurodegenerative disorders, a large majority of them only help with associated symptoms. This lack of pathogenesis-targeting therapies is primarily due to the restrictive effects of the blood-brain barrier (BBB), which keeps close to 99% of all "foreign substances" out of the brain. Since their discovery, nanoparticles have been successfully used for targeted delivery into many organs, including the brain. This review briefly describes the pathophysiology of Alzheimer's, Parkinson's…

Citation impact

815
total citations
FWCI
85.71
Percentile
100%
References
156
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • Medicine
  • Current (fluid)
  • Neuroscience
  • Intensive care medicine
  • Computational biology
  • Biology
  • Engineering
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding