Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron
Beth Israel Deaconess Medical Center · Ragon Institute of MGH, MIT and Harvard
Abstract
Abstract The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike protein 1 . Cellular immune responses, particularly CD8 + T cell responses, probably contribute to protection against severe SARS-CoV-2 infection 2–6 . Here we show that cellular immunity induced by current vaccines against SARS-CoV-2 is highly conserved to the SARS-CoV-2 Omicron spike protein. Individuals who received the Ad26.COV2.S or BNT162b2 vaccines demonstrated durable spike-specific CD8 + and CD4 + T cell responses, which showed extensive cross-reactivity against both the Delta and the Omicron…
Citation impact
- FWCI
- 45.56
- Percentile
- 100%
- References
- 20
Authors
13- JLJinyan LiuCorresponding
Beth Israel Deaconess Medical Center
- ACAbishek Chandrashekar
Beth Israel Deaconess Medical Center
- DSDaniel Sellers
Beth Israel Deaconess Medical Center
- JBJulia Barrett
Beth Israel Deaconess Medical Center
- CJCatherine Jacob-Dolan
Beth Israel Deaconess Medical Center, Ragon Institute of MGH, MIT and Harvard
Topics & keywords
- Biology
- CD8
- Immunity
- Virology
- Immune system
- Effector
- Context (archaeology)
- Antibody
- Good health and well-being