reviewInternational Journal of Molecular SciencesJan 25, 2022GOLD OA

Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover

CCChu-Han ChengLCLi-Ru ChenKCKuo-Hu Chen

Mackay Memorial Hospital · National Yang Ming Chiao Tung University · +2 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Osteoporosis is a serious health issue among aging postmenopausal women. The majority of postmenopausal women with osteoporosis have bone loss related to estrogen deficiency. The rapid bone loss results from an increase in bone turnover with an imbalance between bone resorption and bone formation. Osteoporosis can also result from excessive glucocorticoid usage, which induces bone demineralization with significant changes of spatial heterogeneities of bone at microscale, indicating potential risk of fracture. This review is a summary of current literature about the molecular mechanisms of actions, the risk factors, and treatment of estrogen deficiency related osteoporosis (EDOP) and glucocorticoid induced…

Citation impact

523
total citations
FWCI
39.24
Percentile
100%
References
111
Citations per year

Authors

3

Topics & keywords

Topics
Keywords
  • RANKL
  • Endocrinology
  • Osteocyte
  • Osteoclast
  • Internal medicine
  • Osteoblast
  • Osteoporosis
  • Osteoprotegerin
UN Sustainable Development Goals
  • Good health and well-being
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