Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential
University of British Columbia · Jining Medical University · +3 more institutions
Abstract
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to arise as the disease progresses. A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic link between amyloid β (Aβ) and tau pathology and thus may serve as an obligatory relay of the cognitive impairment in AD. Brain-derived neurotrophic factors (BDNFs) play an important role in maintaining synaptic plasticity in learning and memory. Considering AD as a synaptic disorder, BDNF has attracted increasing attention as a potential diagnostic biomarker and a therapeutical molecule for AD. Although depletion of BDNF has been linked with Aβ accumulation, tau…
Citation impact
- FWCI
- 48.86
- Percentile
- 100%
- References
- 457
Authors
4- LGLina GaoCorresponding
University of British Columbia, Jining Medical University
- YZYun Zhang
Capital Medical University
- KSKeenan Sterling
University of British Columbia
- WSWeihong Song
University of British Columbia, Capital Medical University, Wenzhou Medical University, Zhejiang Lab, Jining Medical University
Topics & keywords
- Neuroscience
- Neurotrophic factors
- Neuroinflammation
- Synaptic plasticity
- Brain-derived neurotrophic factor
- Neurotrophin
- Neurology
- Psychology
- Good health and well-being