articleNature NeuroscienceFeb 1, 2022HYBRID OA

Large-scale deep multi-layer analysis of Alzheimer’s disease brain reveals strong proteomic disease-related changes not observed at the RNA level

ECErik C. B. JohnsonKCKathleen CarterEBEric B. DammerDMDuc M. DuongESEkaterina S. Gerasimov

Emory University · Banner Sun Health Research Institute · +9 more institutions

PubMed
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Abstract

The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain tissues to reveal new AD-related protein co-expression modules that were highly preserved across cohorts and brain regions. Nearly half of the protein co-expression modules, including modules significantly altered in AD, were not observed in RNA networks from the same cohorts and brain regions, highlighting the proteopathic nature of AD. Two such AD-associated modules unique to the proteomic network included a module related to MAPK signaling and metabolism and a module related to the matrisome. The matrisome module was influenced by…

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Topics & keywords

Topics
Keywords
  • Neuropathology
  • Proteome
  • Biology
  • Disease
  • Cognitive decline
  • Neuroscience
  • Neurodegeneration
  • microRNA
UN Sustainable Development Goals
  • Good health and well-being
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