The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting signalling pathways. One such pathway that has garnered much attention in the field of cancer research over the last decade is the Hippo signalling pathway. Consisting of two antagonistic modules, the pathway plays an integral role in both tumour suppressive and oncogenic processes, generally via regulation of a diverse set of genes involved in a range of biological functions. This review discusses the history of the pathway within the context of cancer and explores some of the most recent discoveries as to how this critical transducer of cellular signalling can influence cancer progression. A special focus is on the…

• WT
  Wellcome Trust

  Award: ISSF3
• BC
  Bone Cancer Research Trust
• L
  LifeArc
• JH
  June Hancock Mesothelioma Research Fund
• IS
  International Seafood Sustainability Foundation
• UO
  University of Edinburgh

  Award: 19-0238