articleMutagenesisJan 1, 2022GREEN OA

The BlueScreen HC assay to predict the genotoxic potential of fragrance materials

YTYax ThakkarKJKaushal JoshiCHChristina HickeyJWJ. WahlerBWB. Wall

Research Institute for Fragrance Materials · Firmenich (United States) · +14 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

BlueScreen HC is a mammalian cell-based assay for measuring the genotoxicity and cytotoxicity of chemical compounds and mixtures. The BlueScreen HC assay has been utilized at the Research Institute for Fragrance Materials in a safety assessment program as a screening tool to prioritize fragrance materials for higher-tier testing, as supporting evidence when using a read-across approach, and as evidence to adjust the threshold of toxicological concern. Predictive values for the BlueScreen HC assay were evaluated based on the ability of the assay to predict the outcome of in vitro and in vivo mutagenicity and chromosomal damage genotoxicity assays. A set of 371 fragrance materials was assessed in the BlueScreen…

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386
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Authors

18

Topics & keywords

Topics
Keywords
  • Genotoxicity
  • In vitro toxicology
  • In vivo
  • Chemistry
  • In vitro
  • Computational biology
  • Cytotoxicity
  • Toxicology
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