SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19
Institute of Immunology and Physiology · South Ural State University
Abstract
The review aims to consolidate research findings on the molecular mechanisms and virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and their relevance to four typical stages in the development of acute viral infection. These four stages are invasion; primary blockade of antiviral innate immunity; engagement of the virus's protection mechanisms against the factors of adaptive immunity; and acute, long-term complications of COVID-19. The invasion stage entails the recognition of the spike protein (S) of SARS-CoV-2 target cell receptors, namely, the main receptor (angiotensin-converting enzyme 2, ACE2), its…
Citation impact
- FWCI
- 26.61
- Percentile
- 100%
- References
- 346
Authors
4Topics & keywords
- Immunology
- Immunity
- Biology
- Innate immune system
- Acquired immune system
- Coronavirus
- Virus
- Immune system
- Good health and well-being