articleThe Lancet MicrobeJan 25, 2022GOLD OA

The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries

MHMartin HoeniglDSDanila SeidelACAgostinho CarvalhoSMShivaprakash M RudramurthyAAAmir Arastehfar

University of California, San Diego · Medical University of Graz · +14 more institutions

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Abstract

Reports of COVID-19-associated mucormycosis have been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes. Patients with diabetes and hyperglycaemia often have an inflammatory state that could be potentiated by the activation of antiviral immunity to SARS-CoV2, which might favour secondary infections. In this Review, we analysed 80 published and unpublished cases of COVID-19-associated mucormycosis. Uncontrolled diabetes, as well as systemic corticosteroid treatment, were present in most patients with COVID-19-associated mucormycosis, and rhino-orbital cerebral mucormycosis was the most frequent disease. Mortality was high at 49%, which was particularly due to…

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431
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100%
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Authors

17
  • MH
    Martin HoeniglCorresponding

    University of California, San Diego, Medical University of Graz

  • DS
    Danila Seidel

    University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases

  • AC
    Agostinho Carvalho

    University of Minho

  • SM
    Shivaprakash M Rudramurthy

    Post Graduate Institute of Medical Education and Research

  • AA
    Amir Arastehfar

    Hackensack Meridian Health, Center for Discovery

Topics & keywords

Topics
Keywords
  • Mucormycosis
  • Diabetes mellitus
  • Disease
  • Incidence (geometry)
  • Mycosis
  • Immunity
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