articleNatureJan 31, 2022HYBRID OA

T cell responses to SARS-CoV-2 spike cross-recognize Omicron

RKRoanne KeetonMBMarius B. TinchoANAmkele NgomtiRBRichard BagumaNBNtombi Benede

University of Cape Town · Africa Health Research Institute · +18 more institutions

PubMed
Indexed incrossrefdatacitepubmed

Abstract

Abstract The SARS-CoV-2 Omicron variant (B.1.1.529) has multiple spike protein mutations 1,2 that contribute to viral escape from antibody neutralization 3–6 and reduce vaccine protection from infection 7,8 . The extent to which other components of the adaptive response such as T cells may still target Omicron and contribute to protection from severe outcomes is unknown. Here we assessed the ability of T cells to react to Omicron spike protein in participants who were vaccinated with Ad26.CoV2.S or BNT162b2, or unvaccinated convalescent COVID-19 patients ( n = 70). Between 70% and 80% of the CD4 + and CD8 + T cell response to spike was maintained across study groups. Moreover, the magnitude of Omicron…

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622
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100%
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Topics & keywords

Topics
Keywords
  • Virology
  • Antibody
  • Coronavirus disease 2019 (COVID-19)
  • Biology
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Vaccination
  • Genetics
  • Medicine
UN Sustainable Development Goals
  • Good health and well-being
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